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Nexomics utilizes a number of experimental biophysical techniques to ensure quality control as well as for further understanding of the biological system under study.
MALDI-TOF mass spectroscopy is used as a quality control check for all protein production projects. The technology can also be used to measure regions of disorder within a protein.
Used to evaluate conformational features of proteins, for confirming secondary structure, and identifying regions of disorder in the protein structure.
Limited proteolysis can be valuable for enhancing the crystallization propensity of proteins.
Static/Dynamic Light Scattering
Light scattering data are useful for confirming oligomerization states of protein (e.g., monomer, dimer, etc.). And for determining shape-independent molecular weights.
Lights scattering studies are also valuable for construct optimization to enhance crystallization propensities of proteins.
1D / 2D NMR can be used to assess sample quality, purity and stability.
NMR screening can be used to identify interacting ligands and protein partners.
BLI optical analytical technique to evaluate and characterize bimolecular interactions.
It can be used in assay development and to determine protein interaction affinities.