:q Nexomics Biosciences, Inc. | Protein Production, Structural Biology, Bioinformatics, Discovery

Help Find Solution for COVID-19

 

Structure Based Drug Discovery

 

Proven Experience: personnel and expertise derive from the NIH funded Northeast Structural Genomics Consortium

 

Quality and Speed

 




What We Do?

Nexomics Biosciences functions as a contract research organization (CRO), offering a broad array of gene-to-structure services to the biopharmaceutical community. With a strong focus on discovery and analytical R&D services, our core capabilities include target selection and construct design using bioinformatics tools, cloning of genes into protein production vectors, recombinant protein expression, laboratory-scale fermentation, protein purification, hydrogen deuterium exchange of protein, crystallization screening, small compound screening, NMR metabolomics studies, NMR resonance assignment, NMR structural studies, Cryo-EM structural studies, X-ray crystallographic structural studies, and functional assay development.

Our Services

 
 

High quality three-dimensional protein/RNA structures solved using nuclear magnetic resonance (NMR), cryogenic electron microscopy (cryo-EM) and/or X-ray crystallography techniques enable drug design & compound optimization.

 
 

Nuclear magnetic resonance (NMR) services are available to support a variety of discovery & analytical needs, including small-molecule screening, protein-protein interactions, and bio-equivalence. We specialize in analysis of NMR resonance assignments and 3D structures of proteins or RNAs and complexes.

 
 

Nexomics has over 20 years experience in expressing and purifying challenging proteins, using both prokaryotic and eukaryotic expression systems. We are particularly expert in producing isotope-enriched proteins for NMR and mass spectrometry studies.

 
 

Supplemental studies provide quality assurance include Mass Spectroscopy, analytical gel filtration with static Light scattering, bilayer interferometry, thermofluor binding studies, and hydrogen deuterium exchange of protein

 
 

Nexomics license bioinformatics and scientific software, developed by NESG, include Primer Prim'er for primer design, AutoAssign for NMR backbone assignment, , AutoStructure and ASDP for NOESY data analysis and structure determination

 
 

Catalogue of stock and on-demand proteins to support client discovery needs. These include isotope-enriched protein standards for NMR and mass spectrometry, and NMR / X-ray structure pairs useful for the development of new structure analysis methods.