Structural Biology
Nuclear Magnetic Resonance
X-ray Crystallography Structures
Cryogenic Electron Microscopy (cryo-EM) Structures
Homology Modeling
Nuclear Magnetic Resonance
Nexomics Biosciences has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis, and structure determination.
NMR Data collection
- 500 MHz (cryoprobe, AutoSampler) Bruker
- 600 MHz (cryoprobe, AutoSampler) Bruker
- 700 MHz (cryoprobe, SampleJet) Bruker
- 800 MHz (cryoprobe, AutoSampler) Bruker
- Probes include 19F, 31P and 1H, 2H, 13C, 15N-TR NMR
- Non-Uniform Sampling (NUS) available
NMR Spectral analysis
- Backbone assignments
- Side-chain assignment
- Protein-Protein, Protein/RNA-ligand, Protein-Nucleic Acid complex analysis
- Dynamics, disorder, stability
- Biosimilarity analysis
- ligand binding screening
Structure Determination
- Three-dimensional protein structure determination and quality assessment.
- Ligand-protein complexes
- Protein-protein complexes